Blueberry Stem Extract Suppresses Blue Light-Emitting Diode Light-Induced Endoplasmic Reticulum Stress on Retinal Photoreceptor Cells

Background: Blue light causes retinal photoreceptor damage via oxidative and endoplasmic reticulum (ER) stress. A previous study showed that blueberry stem extract (BStEx) its active components have cytoprotective effects against blue-light-induced cell by suppressing This demonstrated the inhibitory effect of BStEx blue light-induced ER stress in cells. Methods: The cells treated with or antioxidant N-Acetyl-L-cysteine (NAC) as a positive control were used then exposed to light. NAC evaluated using CCK-8. stress-related protein expression changes over time, levels measured after each exposure time NAC. Results: protective morphological abnormalities damage. Although triggered factors such BiP, PERK, ATF6, eIF2α, ATF4, CHOP, which turn stimulated cycle arrest p53 p21 upregulation apoptosis-inducing caspase-3. However, suppressed increase p53, p21, caspase-3, but not mitochondrial apoptotic Bax cytochrome c. Furthermore, similar suppressive on BStEx. Conclusion: Our findings suggest is primarily caused stress, might suppress an effect. contributes proliferative capacity suppression apoptosis